REDUCTION: reduction in the number of animals used for a specific study
REFINEMENT: improvement of experimental design to reduce stress and suffering to animals
REPLACEMENT: replacement (even partial) of animal testing with alternative methods of comparable validity.
3Rs summarize the ethical principles that researchers should respect when they undertake animal experiments.
As well anticipated by the Meeting’s title, The role of 3Rs in the age of One Health: where we are and where we’re going, the meeting, bringing together several scientists who are applying the 3Rs’ principles, would like to give an insight into the present-day situation and propose new ideas to move towards the future of the 3Rs. To this end the meeting will have several topics covering different aspects of the 3Rs’ thinking:
- 3Rs’ implementation in cosmetics R&D;
- Synthesis and use of biomaterials and/or engineered tissues to reduce or avoid animal models;
- Use of bioreactors and microfluidic devices to improve in vitro studies;
- New methodologies for safe and sustainable chemicals and (nano)materials synthesis;
- New alternatives for in vivo validation including 3D cell cultures, or organoids and other robust alternative animal models.
- Refinements methods, such as in silico and statistical approaches, that can help researcher in reducing animal number with the aim to improve experimental design and significantly help to reduce the actual severity of specific scientific procedures and models.
Furthermore, the meeting wants to introduce the participants to the Italian and European 3Rs’ normative as well as how teaching may further increase 3Rs’ future.
We expect that participants could share novel ideas, novel data, discoveries, and future perspective by oral and poster presentations, emphasizing the great opportunity offered by 3Rs application.
The target audience for this conference is basic, translational and computational scientists, as well as young investigators who wants approach 3Rs in their research field.